ChemicalBook CAS DataBase List 3-Pyridinol, 2-amino-5-nitro-

3-Pyridinol, 2-amino-5-nitro- synthesis

4synthesis methods

Product Name:3-Pyridinol, 2-amino-5-nitro-
CAS Number:908248-27-1
Molecular formula:C5H5N3O3
Molecular Weight:155.11

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Yield:908248-27-1 86%

Reaction Conditions:

Stage #1: 6-nitro-2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-onewith sodium hydroxide;water in ethanol at 80; for 3 h;
Stage #2: with hydrogenchloride;sodium carbonate in ethanol;water; pH=8;

Steps:

30.3

A solution of sodium hydroxide (500 mmol) in water (180 ml) was added to a solution of 6- nitrooxazolo[4,5-b]pyridin-2(3H)-one (124 mmol) in ethanol (100 ml) and the reaction mixture was heated at 80 °C for 3 h. The reaction mixture was quenched with concentrated hydrochloric acid (40 mL) and the pH adjusted to 8 with 2 M sodium carbonate. The precipitated solids were collected by filtration to provide 2-amino-5-nitropyridin-3-ol in 86% yield as a yellow solid.

References:

WO2009/23844,2009,A2 Location in patent:Page/Page column 120-121

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References

16867-03-1 Synthesis

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References

60832-72-6 Synthesis

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

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908248-27-1
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References