ChemicalBook CAS DataBase List 3-(Trifluoromethyl)benzaldehyde

3-(Trifluoromethyl)benzaldehyde synthesis

9synthesis methods

Product Name:3-(Trifluoromethyl)benzaldehyde
CAS Number:454-89-7
Molecular formula:C8H5F3O
Molecular Weight:174.12

349-75-7
239 suppliers
$9.00/5g

454-89-7
371 suppliers
$14.00/25g

Yield:454-89-7 98%

Reaction Conditions:

with sodium hypochlorite solution;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;potassium carbonate;isocyanuric acid in ethyl acetate; pH=> 12 at 0 - 10; for 5 h;

Steps:

General Procedure for the oxidation of alcohols employing nitroxyl radical / imide / NaOCl in the presence of K₂CO₃.
General procedure: To a mixture of the alcohol (3.839 mmol), K₂CO₃ (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10°C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.

References:

Fukuda, Naohiro;Izumi, Minoru;Ikemoto, Tomomi [Tetrahedron Letters,2015,vol. 56,# 25,p. 3905 - 3908] Location in patent:supporting information

FullText

201230-82-2 Synthesis