Ethyl 4-Methyl-2-(MethylaMino)thiazole-5-carboxylate synthesis
- Product Name:Ethyl 4-Methyl-2-(MethylaMino)thiazole-5-carboxylate
- CAS Number:3161-68-0
- Molecular formula:C8H12N2O2S
- Molecular Weight:200.26
598-52-7
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609-15-4
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3161-68-0
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Yield:3161-68-0 99%
Reaction Conditions:
with sodium hydrogencarbonate in neat (no solvent) at 75; for 0.333333 h;
Steps:
2.General procedure for the synthesis of4-methyl(ortrifluoromethyl)-2-(methylamino) 1,3-thiazole- 5-carbohydrazide M2
General procedure: Equivalent 1-methylthiourea, ethyl 2-chloro-3-oxobutanoate or ethyl2-chloro-4,4,4-trifluoro-3-oxobutanoate and NaHCO3 were added to around bottom flask, the mixture was heated to 75 oC for 20 minutes.The reaction mixture was poured over crushed ice and allowed to precipitate.The precipitate was lter through vacuum and the product was recrystallizedusing absolute alcohol to getM1a or M1b in 99% and 88% yield.Amixtureof the M1 (10mmol) and hydrazine hydrate (20mmol) in ethanolwas stirred atroom temperature for 3 h and then ltered1. The crude productrecrystallized from absolute alcohol to get M2a or M2b in 80% or 75%yield.
References:
He, Haifeng;Wang, Xiaoyan;Shi, Liqiao;Yin, Wenyan;Yang, Ziwen;He, Hongwu;Liang, Ying [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 14,p. 3263 - 3270] Location in patent:supporting information
141-97-9
766 suppliers
$5.00/25g
598-52-7
182 suppliers
$6.00/1g
3161-68-0
22 suppliers
$52.00/500mg