ChemicalBook CAS DataBase List 4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid

4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid synthesis

9synthesis methods

Product Name:4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid
CAS Number:340736-76-7
Molecular formula:C10H5F3N2O3
Molecular Weight:258.15

trifluoroMethyl-1,2,4-oxadiazol-3-yl)benzoate

340736-74-5
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4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoicacid

340736-76-7
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$15.00/100mg

Yield:340736-76-7 79%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran at 0 - 25; for 16 h;

Steps:

1.4 Step 4: 4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid.

To a stirred solution of methyl 4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoate (15 g, 55.1 mmol) in tetrahydrofuran (120 mL), a solution of sodium hydroxide (4.0 g, 99 mmol) in water (30 mL) was added dropwise by a dropping funnel at 0 °C. The resulting reaction mixture was stirred for 16 h at 25 ^oC. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. Water (50 mL) was added to the residue and cooled to 0 °C and acidified to pH 3 with 3N aqueous hydrochloric acid. The precipitate was collected by filtration, washed with water, and dried to obtain 4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid (11.2 g, 43.4 mmol, 79 % yield).

References:

WO2019/150219,2019,A2 Location in patent:Paragraph 65

407-25-0 Synthesis