4-(2-METHOXY-ETHOXY)-PHENOL synthesis

4synthesis methods

Product Name:4-(2-METHOXY-ETHOXY)-PHENOL
CAS Number:51980-60-0
Molecular formula:C9H12O3
Molecular Weight:168.19

623-05-2 Synthesis

623-05-2
659 suppliers
$5.00/100mg

6482-24-2 Synthesis

6482-24-2
278 suppliers
$9.00/1g

51980-60-0
34 suppliers
$10.00/100mg

Yield:51980-60-0 58.6%

Reaction Conditions:

with 18-crown-6 ether;potassium carbonate in acetone; for 72 h;Reflux;

Steps:

6.1

2.34g (20mmol) was dissolved in methanol paraben 50mL of acetone, stirred successively added 2-bromoethyl methyl ether3.31g (24mmol), 40mg of 18-crown-6, potassium carbonate 8.29g (60mmol), refluxed for 72h. Inorganic salt was removed by suction,The acetone mother liquor was removed under reduced pressure, dissolved in ethyl acetate was added, extracted with saturated brine, the organic layer was dried over anhydrous sodium sulfate,Silica gel column chromatography (PE: EA = 10: 1 (v / v)), to give a colorless liquid ((4- (2-methoxyethoxy) benzyl alcohol), a yield of 58.6%

References:

CN105541833,2016,A Location in patent:Paragraph 0102; 0104; 0105