4,5,6,7-tetrahydro-1H-indazol-3-Amine synthesis
- Product Name:4,5,6,7-tetrahydro-1H-indazol-3-Amine
- CAS Number:41832-27-3
- Molecular formula:C7H11N3
- Molecular Weight:137.18
4513-77-3
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$24.00/100mg
41832-27-3
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$344.00/1g
Yield:41832-27-3 93%
Reaction Conditions:
with hydrazine hydrate in ethanol;Reflux;
Steps:
[0893] Step 1
[0894] A solution of 2-oxocyclohexanecarbonitrile (500 mg, 4.06 mmol) and hydrazine hydrate (410 mg, 8.2 mmol) in EtOH (10 mL) was stirred at reflux overnight. The solvent was removed in vacuo and the resulting yellow residue 4,5,6,7-tetrahydro-2H-indazol-3- amine (520 mg, 93%) was used without purification. 1H NMR (500 MHz, Chloroform -i) δ 4.21 (s, 3H), 2.54 (t, J= 5.5 Hz, 2H), 2.32 (t, J= 5.4 Hz, 2H), 1.83 - 1.67 (m, 4H).
References:
WO2019/32720,2019,A1 Location in patent:Paragraph 0893-0894