4-ACETAMIDOPHENYLACETONITRILE synthesis
- Product Name:4-ACETAMIDOPHENYLACETONITRILE
- CAS Number:25025-06-3
- Molecular formula:C10H10N2O
- Molecular Weight:174.2
3544-25-0
286 suppliers
$10.00/5g
108-24-7
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$14.00/250ML
25025-06-3
61 suppliers
$24.00/1g
Yield:25025-06-3 72%
Reaction Conditions:
with sodium acetate
Steps:
5.1
Sodium acetate anhydrous (3.10 g, 37.8 mmol), was added to a solution of 4- aminophenylacetonitrile (5.00 g, 37.8 mmol) in acetic anhydride (10 ml). The reaction mixture was heated at reflux temperature overnight, before being concentrated in vacuo. The residue was taken up in dichloromethane (20 ml) and washed successively with 1M sodium hydroxide aq. solution (40 ml), 1M HCI aq. (20 ml) and water (2 x 20 ml). The organic extract was dried over magnesium sulfate, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography [dichloromethane/0-5% methanol] in order to obtain the title compound as a beige solid (4. 74g, 72%)
References:
ARAKIS LTD. WO2005/84658, 2005, A1 Location in patent:Page/Page column 11
3544-25-0
286 suppliers
$10.00/5g
25025-06-3
61 suppliers
$24.00/1g
3544-25-0
286 suppliers
$10.00/5g
75-36-5
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$17.92/100G
25025-06-3
61 suppliers
$24.00/1g