4-broMo-1-(2-Methoxyethyl)-1H-pyrazole synthesis
- Product Name:4-broMo-1-(2-Methoxyethyl)-1H-pyrazole
- CAS Number:847818-49-9
- Molecular formula:C6H9BrN2O
- Molecular Weight:205.06
Yield: 93%
Reaction Conditions:
with tetrabutylammomium bromide;sodium hydroxide in water;dimethyl sulfoxide at 20;
Steps:
10 Synthesis of 4-bromo-1-(2-methoxyethyl)-1H-pyrazole
4-bromopyrazole (14.7 g, 0.1 mol), 2-bromoethyl methyl ether (13.9 g, 0.1 mol), at room temperatureTetrabutylammonium bromide (2.6 g, 0.008 mol), dissolved in 8 ml of dimethyl sulfoxide (DMSO), and added with sodium hydroxide solution [sodium hydroxide solution: 8.8 g (0.22 mol) of hydroxide a solution obtained by dissolving sodium in 20 ml of water],The reaction is exothermic. After the addition is completed, it is stirred at room temperature overnight, and diluted with water.Extracted with dichloromethane, dried, concentrated and distilled under reduced pressure.The product was 19.1 g, and the yield was 93%.
References:
Changsha Luxing Biological Technology Co., Ltd.;Tan Yongjun CN108863936, 2018, A Location in patent:Paragraph 0037; 0038
