ChemicalBook CAS DataBase List 4-Bromo-3,6-dichloropyridazine

4-Bromo-3,6-dichloropyridazine synthesis

4synthesis methods

Product Name:4-Bromo-3,6-dichloropyridazine
CAS Number:10344-42-0
Molecular formula:C4HBrCl2N2
Molecular Weight:227.87

540-80-7
358 suppliers
$29.00/25g

823-58-5 Synthesis

823-58-5
146 suppliers
$9.00/1g

10344-42-0
83 suppliers
$45.00/50mg

Yield:10344-42-0 50.38%

Reaction Conditions:

with copper(II) bromide in acetonitrile at 60; for 4 h;Cooling with ice;

Steps:

1 Synthesis of Compound M7

Add 3,6-dichloropyridazin-4-amine (30g), cuprous bromide (34g), acetonitrile (300mL) to a 500mL three-necked flask, stir to dissolve, slowly add tert-butyl nitrite (23g) under ice bath , the dropwise addition was completed, and then transferred to 60°C for reaction for 4h. After the reaction was completed, the reaction solution was filtered through diatomaceous earth, the filtrate was evaporated to dryness, and purified by column chromatography (PE:EA=10:1) to obtain a white solid (21 g, 50.38% yield), namely compound M7.

References:

WO2022/52886,2022,A1 Location in patent:Page/Page column 20

15456-86-7 Synthesis