(4-Chloro-3-Methoxyphenyl)Methanol synthesis

10synthesis methods

Product Name:(4-Chloro-3-Methoxyphenyl)Methanol
CAS Number:13726-17-5
Molecular formula:C8H9ClO2
Molecular Weight:172.61

85740-98-3 Synthesis

85740-98-3
158 suppliers
$9.00/250mg

13726-17-5
48 suppliers
$45.00/2.5g

Yield:13726-17-5 99%

Reaction Conditions:

in tetrahydrofuran;

Steps:

C C.

C. Synthesis of (4-chloro-3-methoxyphenyl)methan-1-ol To a solution of 4-chloro-3-methoxybenzoic acid (4.88 g, 26.2 mmol) in THF (50 mL) was added borane-THF complex (52 mL 1M solution in THF, 52 mmol) via addition funnel over 10 min. The reaction mixture was refluxed for 2 hr, cooled, extracted with EtOAc, washed with water, 5% Na₂CO₃ and brine, dried and concentrated in vacuo to give (4-chloro-3-methoxyphenyl)methan-1-ol (4.5 g, 99%). ES-MS (M+H-H₂O)+=155, 157 (Cl).

References:

US2002/77486,2002,A1

13726-16-4
94 suppliers
$8.00/1g

13726-17-5
48 suppliers
$45.00/2.5g

References

116022-18-5
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$50.00/25g

13726-17-5
48 suppliers
$45.00/2.5g

References

73909-16-7
43 suppliers
$50.00/1g

13726-17-5
48 suppliers
$45.00/2.5g

References

615-74-7
104 suppliers
$16.00/5g

13726-17-5
48 suppliers
$45.00/2.5g

References