ChemicalBook CAS DataBase List 4-ETHYNYL-BENZOIC ACID

4-ETHYNYL-BENZOIC ACID synthesis

14synthesis methods

Product Name:4-ETHYNYL-BENZOIC ACID
CAS Number:10602-00-3
Molecular formula:C9H6O2
Molecular Weight:146.14

3034-86-4
174 suppliers
$6.00/100mg

10602-00-3
195 suppliers
$10.00/250mg

Yield:10602-00-3 77%

Reaction Conditions:

with lithium hydroxide in methanol;water for 2 h;

Steps:

21 Synthesis of Compound B 11
To a solution of 2 ( 0.5 g, 3.13 mmol) in MeOH (10 ml) was added LiOH (0.312 g. 12.52mmol) in water (10 ml). The mixture was stirred for 2 h then quenched by HCI solution (2N) extracted with EtOAc (30 ml x 3). The combined organic was dried over anhydrous Na2SO4 concentrated to give the desired intermediate 3 (0.35 g, 77%) as yellow solid.

References:

HANGZHOU ZYLOX PHARMA CO., LTD.;WANG, Bing;ZHAO, Jonathon Zhong WO2014/82286, 2014, A1 Location in patent:Paragraph 67

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