4-Hydroxybenzhydrazide synthesis
- Product Name:4-Hydroxybenzhydrazide
- CAS Number:5351-23-5
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
99-76-3
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5351-23-5
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Yield:5351-23-5 94.6%
Reaction Conditions:
with hydrazine hydrate in methanol for 0.05 h;Microwave irradiation;
Steps:
General procedure for synthesis of substituted acid hydrazide:
General procedure: The benzoic acid hydrazides, 3a-h were prepared accordingto reported method in literature28,29 with some desirablemodifications. The ester (2a-h, 0.1 mol) dissolved inappropriate volume of methanol was transferred to a flaskwith a reflux condenser. Hydrazine hydrate (99%, 0.15 mol) was slowly added to the mixture and then kept on reflux forabout 5-6 h. The excess of solvent and hydrazine hydratewere distilled off. On addition of water the product separatedout which was washed several times with distilled water anddried. The product was recrystallized from 80% aqueous ethanoland melting points determined (Table 2).Microwave method: The same procedure as stated abovewas adopted using 100 ml methanol following the other conditionsof microwave in a microwave reactor at 350 Watt(power) for 3-5 min. Precipitation and separation of precipitatewas done as for conventional method (Table 2).
References:
Upadhyay, Prabhat Kumar;Mishra, Pradeep [Journal of the Indian Chemical Society,2018,vol. 95,# 6,p. 661 - 666]
120-47-8
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5351-23-5
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99-96-7
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5351-23-5
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28141-24-4
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5351-23-5
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123-08-0
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5351-23-5
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