4-Methoxyphthalic acid synthesis
- Product Name:4-Methoxyphthalic acid
- CAS Number:1885-13-8
- Molecular formula:C9H8O5
- Molecular Weight:196.16
22895-19-8
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1885-13-8
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$8.00/100mg
Yield: 99%
Reaction Conditions:
Stage #1:dimethyl 4-methoxyphtalate with potassium hydroxide;water in methanol for 4 h;Heating / reflux;
Stage #2: with hydrogenchloride in water; pH=<= 2
Steps:
C.C2
A solution of dimethyl 4-methoxyphthalate (36.75 g, 0.16 mol) in methanol (100 ml) was treated with a solution of potassium hydroxide (28.0 g, 0.5 mol) in water (50 ml) and the mixture was stirred and held at reflux for 4 hours. Upon cooling to room temperature the methanol was removed in vacuo and the mixture acidified to pH 2 or below by the addition of 5M hydrochloric acid. The solid material was filtered off, washed with water and sucked dry under reduced pressure overnight to afford 4-methoxyphthalic acid (31.8 g, 99%) as an off white solid. 1H NMR (DMSOd6) 12.90 (2H, br s), 7.74 (1H, d), 7.12-7.05 (2H1 m), 3.84 (3H, s). MS: [M+H]+ 197.
References:
ASTEX THERAPEUTICS LIMITED WO2008/44029, 2008, A1 Location in patent:Page/Page column 203
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1885-13-8
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$8.00/100mg
86-90-8
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124-41-4
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1885-13-8
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$8.00/100mg
610-35-5
234 suppliers
$9.00/1g
1885-13-8
101 suppliers
$8.00/100mg