4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis

5synthesis methods

Product Name:4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL
CAS Number:93378-56-4
Molecular formula:C15H13N3S
Molecular Weight:267.35

103556-07-6
7 suppliers
inquiry

4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL

93378-56-4
16 suppliers
$147.00/100mg

Yield:93378-56-4 81%

Reaction Conditions:

with sodium hydroxide in water;Reflux;

Steps:

4.5.2. General procedure for the synthesis of 5-substituted-4-phenyl-4H-1,2,4-triazole-3-thiol (3f-3l)

General procedure: Various substituted carboxylic acid hydrazides (25.0 mmol) andphenyl isothiocyanate (25.0 mmol) were dissolved in toluene (30 ml).The reaction mixture was heated for 1-2 h. After completion of thereaction, toluene was evaporated using a rotary evaporator. The resultingprecipitates were filtered, washed with water, and recrystallizedfrom ethanol. Recrystallized thiosemicarbazides 7 was further refluxedwith 4 N sodium hydroxide for 4-5 h. After completion of cyclization,reaction mixture was acidified with dilute hydrochloric acid (adjustedpH 5-6). The resulting precipitates of 1,2,4-triazole-3-thiols 3f-3l werecollected through filtration, washed with water and recrystallized fromethanol.

References:

Shahzad, Sohail Anjum;Yar, Muhammad;Khan, Zulfiqar Ali;Shahzadi, Lubna;Naqvi, Syed Ali Raza;Mahmood, Adeem;Ullah, Sami;Shaikh, Ahson Jabbar;Sherazi, Tauqir Ali;Bale, Adebayo Tajudeen;Kuku?owicz, J?drzej;Bajda, Marek [Bioorganic Chemistry,2019,vol. 85,p. 209 - 220]

5351-69-9 Synthesis