ChemicalBook CAS DataBase List 4-tert-Butylphenyl-acetonitrile

4-tert-Butylphenyl-acetonitrile synthesis

11synthesis methods

Product Name:4-tert-Butylphenyl-acetonitrile
CAS Number:3288-99-1
Molecular formula:C12H15N
Molecular Weight:173.25

18880-00-7 Synthesis

18880-00-7
197 suppliers
$9.00/5g

3288-99-1
235 suppliers
$15.00/5g

Yield:3288-99-1 99%

Steps:

1 EXAMPLE 1

EXAMPLE 1 This Example illustrates the preparation of 4-[3-(p- t -butylphenyl)- cis -cyclobutylmethyl]-2,6- cis -dimethylmorpholine (Compound No.3.1 in Table 1). A mixture of p- t -butylbenzyl bromide (20.44 g, 0.09 mol) and potassium cyanide (11.72 g, 0.18 ml) in a saturated solution of 18-crown-6 (50 ml) was refluxed at 80°C for 5 hours. After cooling to room temperature the solution was poured into water, extracted with dichloromethane and dried over anhydrous sodium sulphate. Removal of the solvent gave a yellow liquid which was purified by column chromatography (silica eluted with petroleum ether/ethyl acetate 9:1) to give p- t -butylbenzyl cyanide (15.4 g, 99%).

References:

EP253501,1990,A3