ChemicalBook CAS DataBase List 4-TERT-BUTYLTHIOPHENOL

4-TERT-BUTYLTHIOPHENOL synthesis

8synthesis methods

Product Name:4-TERT-BUTYLTHIOPHENOL
CAS Number:2396-68-1
Molecular formula:C10H14S
Molecular Weight:166.28

4-tert-Butylthiophenol can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes. A mixture of tert-butyl 4-(tert-butyl)phenyl sulfide, thiophenol, and boron trifluoride-phosphoric acid complex was heated slowly to 90° C, and stirred for four hours, cooled to 25° C. The organic layer was purified to give 4-tert-Butylthiophenol.

15084-51-2 Synthesis

15084-51-2
220 suppliers
$8.00/5g

2396-68-1
197 suppliers
$8.00/1g

Yield:2396-68-1 93.7%

Reaction Conditions:

with hydrogenchloride;chlorosulfonic acid;sodium sulfide;iron;triphenylphosphine in water at 200; for 4 h;Solvent;Reagent/catalyst;Temperature;

Steps:

2; 7
60.0 g of p-tert-butylbenzenesulfonyl chloride, 250 ml of water and 150 ml of chlorosulfonic acid were added to the reaction vessel, mechanically stirred, and 1.3 g of triphenylphosphine, 5.7 g of iron and 34 g of sodium sulfide were added, and reacted at 200 ° C for 4 hours.TLC tracking monitoring.Allow to stand, separate the water layer, adjust the pH to 1.0, and concentrate the organic phase after extraction.Distillation under reduced pressure gave 40.3 g of p-tert-butylthiophenol in a yield of 93.7%.

References:

Tianjin Ruiling Chemical Co., Ltd.;Lu Bowei;Xie Zhiqiang;Yang Shuxun;Liu Yajun CN108863870, 2018, A Location in patent:Paragraph 0021-0022; 0031-0032

FullText