ChemicalBook CAS DataBase List 4-(TRIETHYLSILYL)-3-BUTYN-1-OL

4-(TRIETHYLSILYL)-3-BUTYN-1-OL synthesis

3synthesis methods

Product Name:4-(TRIETHYLSILYL)-3-BUTYN-1-OL
CAS Number:160194-29-6
Molecular formula:C10H20OSi
Molecular Weight:184.35

1-TRIETHYLSILYL-4-(TRIETHLYLSILYLOXY)-1-BUTYNE

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Yield: 96%

Reaction Conditions:

with hydrogenchloride;water in methanol at 20; for 4 h;

Steps:

4-(triethylsilyl)but-3-in-1-ol
4-(triethylsilyl)but-3-in-1-ol Triethyl(4-(triethylsilyl)but-3-inyloxy)silane (32.99 g, 110.66 mmole) was dissolved in MeOH (336 ml), 2N HCl (62 ml) was added, and the mixture was stirred for 4 hours at RT. Hexane (250 ml) and H₂O (200 ml) were then added to the solution and the aqueous phase was extracted with hexane (3*100 ml). The combined organic phases were washed with H₂O (100 ml) and then with saturated NaCl-Solution (50 ml) and dried over MgSO₄. After filtering off the drying agent the solvents were removed on a rotary evaporator. Column chromatography of the residue (hexane/ether=4:1, then ether) yielded 4-(triethylsilyl)but-3-in-1-ol (19.6 g, 96%) as a colourless oil.

References:

GRUNENTHAL GMBH US2009/156593, 2009, A1 Location in patent:Page/Page column 17

994-30-9 Synthesis