Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine synthesis
- Product Name:Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine
- CAS Number:414909-98-1
- Molecular formula:C20H18FNO3
- Molecular Weight:339.36
620-08-6
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414909-98-1
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Yield:414909-98-1 86%
Reaction Conditions:
Stage #1: 2-Bromo-5-fluorotoluenewith iodine;magnesium in tetrahydrofuran at 35 - 70;Inert atmosphere;Reflux;Large scale reaction;
Stage #2: 4-methoxypyridine;benzyl chloroformate in tetrahydrofuran at -20 - 30;Inert atmosphere;Large scale reaction;Comins type reaction;
References:
Di Fabio, Romano;Alvaro, Giuseppe;Griffante, Cristiana;Pizzi, Domenica A.;Donati, Daniele;Mattioli, Mario;Cimarosti, Zadeo;Guercio, Giuseppe;Marchioro, Carla;Provera, Stefano;Zonzini, Laura;Montanari, Dino;Melotto, Sergio;Gerrard, Philip A.;Trist, David G.;Ratti, Emiliangelo;Corsi, Mauro [Journal of Medicinal Chemistry,2011,vol. 54,# 4,p. 1071 - 1079] Location in patent:experimental part
620-08-6
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452-63-1
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7439-95-4
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501-53-1
393 suppliers
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414909-98-1
9 suppliers
inquiry