5,6-diphenyl-1,2,4-triazine-3-thiol synthesis
- Product Name:5,6-diphenyl-1,2,4-triazine-3-thiol
- CAS Number:37469-24-2
- Molecular formula:C15H11N3S
- Molecular Weight:265.33
79-19-6
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$14.00/1g
134-81-6
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$9.00/25g
37469-24-2
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$60.00/100mg
Yield:37469-24-2 87.82%
Reaction Conditions:
with acetic acid in water; for 4 h;Reflux;
Steps:
Synthesis of 5,6-Diphenyl-4H-[1,2,4]triazine-3-thione
Benzil (6 g, 28.5 mmol) was dissolved in glacial acetic acid (150 mL) and added to a solution of thiosemicarbazide (2.59 g, 28.5 mmol) in hot water (100 mL). The mixture was refluxed for 4 h, and the precipitate that appeared was filtered while the solution was hot. The orange crystals obtained were recrystallized from ethanol to give reddish crystals (yield: 5.27 g, 87.82%, m.p. 222-224 °C).
References:
Arshad, Muhammad Nadeem;Bibi, Aisha;Mahmood, Tariq;Asiri, Abdullah M.;Ayub, Khurshid [Molecules,2015,vol. 20,# 4,p. 5851 - 5874]