5-Aminoisophthalic acid synthesis
- Product Name:5-Aminoisophthalic acid
- CAS Number:99-31-0
- Molecular formula:C8H7NO4
- Molecular Weight:181.15
618-88-2
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$13.00/25g
99-31-0
422 suppliers
$6.00/10g
Yield:99-31-0 95%
Reaction Conditions:
Stage #1:5-nitrobenzene-1,3-dicarboxylic acid with sodium hydroxide in water for 1 h;
Stage #2: with hydrazine hydrate in water at 30 - 35; for 1 h;Concentration;Temperature;
Steps:
2 Example 2:
In a 3 L four-necked flask equipped with a mechanical stirrer, a thermometer was charged 211.1 g (1.0 mol, 1.0 eq) of 5-nitroIsophthalic acid, 160.0 g (4.0 mol, 4.0 eq) of sodium hydroxide in 2 L of water, and the mixture was stirred for 1 hour to clarify the system. Then add 10g of Raney nickel, slowly raise the temperature between 30 ~ 35 , and then drop into the 80% hydrazine hydrate 125.0g (2.0mol, 2.0eq), 30 minutes drop finished, continue stirring for 30 minutes to end the reaction. The pH of the filtrate was adjusted to 3.5 to 4.0 with acetic acid, and a large amount of white solid was precipitated by filtration and dried to obtain 172.0 g of 5-aminoisophthalic acid in a yield of 95% and purity of 99.7% ).
References:
Tianjinxi Zerun Technology Co., Ltd.;Ma, Junli CN106748840, 2017, A Location in patent:Paragraph 0020; 0021; 0022; 0023; 0024; 0025
618-88-2
472 suppliers
$13.00/25g
7440-44-0
277 suppliers
$12.00/25g
99-31-0
422 suppliers
$6.00/10g