5-Bromo-4-(thiophen-2-yl)pyrimidine synthesis
1synthesis methods
- Product Name:5-Bromo-4-(thiophen-2-yl)pyrimidine
- CAS Number:5162-74-3
- Molecular formula:C8H5BrN2S
- Molecular Weight:241.11
Yield:5162-74-3 75%
Reaction Conditions:
Stage #1: thiophene;5-bromopyrimidinewith trifluoroacetic acid
Stage #2: with potassium hydroxide;potassium hexacyanoferrate(III) in water;
References:
Verbitskiy, Egor V.;Cheprakova, Ekaterina M.;Makarova, Nadezhda I.;Dorogan, Igor V.;Metelitsa, Anatoly V.;Minkin, Vladimir I.;Slepukhin, Pavel A.;Svalova, Tatyana S.;Ivanova, Alla V.;Kozitsina, Alisa N.;Rusinov, Gennady L.;Chupakhin, Oleg N.;Charushin, Valery N. [European Journal of Organic Chemistry,2016,vol. 2016,# 7,p. 1420 - 1428]