5-Bromoindole-2-carboxylic acid synthesis
- Product Name:5-Bromoindole-2-carboxylic acid
- CAS Number:7254-19-5
- Molecular formula:C9H6BrNO2
- Molecular Weight:240.05
16732-70-0
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7254-19-5
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Yield:7254-19-5 91%
Reaction Conditions:
Stage #1: ethyl 5-bromoindolecarboxylatewith sodium hydroxide in methanol;water; for 0.5 h;Reflux;Green chemistry;
Stage #2: with hydrogenchloride in methanol;water at 40; pH=3 - 4;Green chemistry;
Steps:
4.3 Synthesis of 5,5-bromoindole-2-carboxylic acid
A mixture of 134 g of 5-bromoindole-2-carboxylic acid ethyl ester in 31.25 g of 96%Sodium hydroxide in 183 ml of methanol and 183 ml of water was heated under reflux for 0.5 hour,Cooled to 40 ° C, 10% hydrochloric acid was added dropwise to a pH of 3 to 4,Filtration gave 109.1 g of an off-white 5-bromoindole-2-carboxylic acid in 91% yield and an HPLC content of ≥96%
References:
CN104402795,2017,B Location in patent:Paragraph 0050; 0053
16382-11-9
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7254-19-5
288 suppliers
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7254-19-5
288 suppliers
$9.00/250mg