5-Methyl-1H-pyrazole-3-carboxylic acid synthesis
- Product Name:5-Methyl-1H-pyrazole-3-carboxylic acid
- CAS Number:402-61-9
- Molecular formula:C5H6N2O2
- Molecular Weight:126.11
4027-57-0
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402-61-9
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Yield: 88%
Reaction Conditions:
with sodium hydroxide;ethanol for 1 h;Heating / reflux;
Steps:
ii.b
To a solution of 5-methylpyrazole-3-carboxylic acid ethyl ester (4.94 g, 32.0 mmol) in abs. EtOH (80 mL) was added NaOH (6.4 g, 160 mmol). The mixture was heated at reflux for 1 h and cooled to 20 C. The mixture was acidified with HC1 (aq., 2 M, 85 mL, 170 mmol) and the pH adjusted to 3 withNaOH (aq., 2 M). The mixture was extracted with EtOAc (200 mL). The organic phase was washed with NaCI (aq, sat, 50 mL) and concentrated to give the title compound (3.54 g, 88 %) as a white solid. 5 ^ NMR (DMSO-ds, 400 MHz) S 12.83 (br. s, 1H). 6.43 (s, 1H), 2.22 (s, 3H).
References:
BIOLIPOX AB WO2006/32851, 2006, A1 Location in patent:Page/Page column 39-40
10010-93-2
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402-61-9
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67-51-6
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3112-31-0
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402-61-9
208 suppliers
$10.00/500mg
67-51-6
519 suppliers
$6.00/25g
402-61-9
208 suppliers
$10.00/500mg
40535-14-6
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402-61-9
208 suppliers
$10.00/500mg