4,8-Dichloroquinoline-3-carboxylic acid ethyl ester synthesis
- Product Name:4,8-Dichloroquinoline-3-carboxylic acid ethyl ester
- CAS Number:56824-91-0
- Molecular formula:C12H9Cl2NO2
- Molecular Weight:270.11
73987-37-8
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56824-91-0
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Yield:56824-91-0 68%
Reaction Conditions:
with trichlorophosphate at 100; for 0.5 h;
Steps:
A mixture of 8-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester (7.94 g, 31.5 mmol; see step (b) above) and POCl3 (6 mL) was stirred at 100 °C for 30 min, cooled and concentrated. The crude material was recrystallised from EtOAc. Yield 5.46 g (68 %) as white flakes. 1H-NMR (CDCl35 400 MHz) δ 9.23 (IH, s), 8.34 (IH, dd), 8.16 (IH5 dd), 7.81 (IH5 dd), 4.44 (2H5 q), 1.39 (3H51).
References:
WO2007/51982,2007,A1 Location in patent:Page/Page column 44
7486-35-3
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347146-23-0
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56824-91-0
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347146-14-9
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56824-91-0
32 suppliers
$35.00/250mg