ChemicalBook CAS DataBase List 6,7,8-TRIMETHOXYCOUMARIN

6,7,8-TRIMETHOXYCOUMARIN synthesis

8synthesis methods

Product Name:6,7,8-TRIMETHOXYCOUMARIN
CAS Number:6035-49-0
Molecular formula:C12H12O5
Molecular Weight:236.22

454-73-9 Synthesis

454-73-9
102 suppliers
$8.00/250mg

Ethyl (triphenylphosphoranylidene)acetate

1099-45-2
358 suppliers
$6.00/5g

6035-49-0
154 suppliers
$62.50/250mg

Yield:6035-49-0 81%

Reaction Conditions:

for 0.25 h;Inert atmosphere;Reflux;

Steps:

General procedure: The appropriate o-hydroxybenzaldehyde (1 mmol) and ethyl(triphenylphosphoranylidene) acetate(1.2 mmol) were dissolved in N,N-diethylaniline (1.5 mL) and the resulting mixture was stirred under aN2 atmosphere and reflux for 15 min. The solvent was removed under reduced pressure (1 mmHg,52 °C) and the resulting brown oil was purified by column chromatography (petroleum ether-ethylacetate, 3:1).

References:

Gao, Wenqing;Li, Qingyong;Chen, Jian;Wang, Zhichao;Hua, Changlong [Molecules,2013,vol. 18,# 12,p. 15613 - 15623]

574-84-5 Synthesis