ChemicalBook CAS DataBase List 6-Fluoronicotinic acid

6-Fluoronicotinic acid synthesis

4synthesis methods

Product Name:6-Fluoronicotinic acid
CAS Number:403-45-2
Molecular formula:C6H4FNO2
Molecular Weight:141.1

2369-19-9 Synthesis

2369-19-9
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$6.00/1g

403-45-2
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$4.00/1g

Yield:403-45-2 11.8 g

Reaction Conditions:

with potassium permanganate;potassium hydroxide in water at 95; for 5 h;Reagent/catalyst;

Steps:

1-5
Example 1:In a 500mL three-necked flask, add 11.1g (0.1mol) 2-fluoro-5-methylpyridine, add 250mL of water, start mechanical stirring, add 31.6g (0.2mol) KMnO4 and 5.6g (0.1mol) KOH successively, oil bath Heat to 95°C, react for 5h, filter while hot, and collect the filtrate. After the filtrate drops to room temperature, adjust the pH value to 2 to 4 with concentrated hydrochloric acid, and solids are precipitated out and filtered; the filtrate is extracted twice with dichloroethane. The filtered solid and the extracted oil are mixed and rotary evaporated to obtain 11.8 g of off-white solid, which is 2-fluoro-5-carboxylic acid pyridine (melting point: 275-278°C).

References:

CN112358442, 2021, A Location in patent:Page/Page column 4; 5

59-67-6 Synthesis