6-Hydroxyhexyl Methanethiosulfonate synthesis
- Product Name:6-Hydroxyhexyl Methanethiosulfonate
- CAS Number:212261-98-8
- Molecular formula:C7H16O3S2
- Molecular Weight:212.33
4286-55-9
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1950-85-2
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212261-98-8
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$739.20/10MG
Yield:212261-98-8 61%
Reaction Conditions:
in ethanol; for 20 h;Heating / reflux;
Steps:
2.1
A mixture of 6-bromo-1-hexanol (2.4 g; 0.013 mol) and sodium methane thiosulfonate (1.95 g; 0.0146 mol) in ethanol (30 mL) was heated at reflux for 20 hours. It was filtered, and 5 g silica gel was added to the filtrate, which was then evaporated to dryness. The residual powder was applied to a column of silica gel, which was eluted with ethyl acetate/hexane (7.5:2.5). The fractions containing 6-hydroxyhexyl methanethiosulfonate were combined and evaporated to dryness, to give a colorless oil (1.64 g; 8.0 mmol; 61% yield).
References:
EP966304,2005,B1 Location in patent:Page/Page column 16