ChemicalBook CAS DataBase List 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid synthesis

3synthesis methods

Product Name:2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid
CAS Number:72217-12-0
Molecular formula:C5H6N4O3S
Molecular Weight:202.19

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

72217-12-0
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Yield: 74.7%

Reaction Conditions:

in sodium hydroxide

Steps:

14 Example 14
Example 14 A solution of ethyl 2-(5-ethoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetate (19.6 mg; 7.15*10^-2 mmol) in aqueous 1N NaOH solution (286 μl; 286*10^-1 mmol) was stirred at 100° C. for 4 hours. After cooling, the mixture was acidified with 6N hydrochloric acid to pH 1. The mixture was extracted with ethyl acetate (0.3ml*5) and the extract was dried over sodium sulfate and then concentrated to give 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetic acid (10.8 mg; yield 74.7%) as white crystals. m.p. 179°-181° C. NMR δ (DMSO-d₆): 3.90(3H.s.CH₃), 8.20(2H.bs.NH₂)

References:

Katayama Seiyakusyo Co. Ltd. US5585494, 1996, A

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72217-12-0
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References

2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-methoxyiminoacetonitrile

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72217-12-0
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References

2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid Related Search:

2,1,3-Benzothiadiazole Ethyl acetate 2-Mercapto-5-methyl-1,3,4-thiadiazole Ethyl 2-(Chlorosulfonyl)acetate Glycine (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO ACETIC ACID 5-Amino-1,2,4-thiadiazole