4-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PHENOXY]-BUTYRIC ACID ETHYL ESTER synthesis
- Product Name:4-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PHENOXY]-BUTYRIC ACID ETHYL ESTER
- CAS Number:859169-90-7
- Molecular formula:C18H27BO5
- Molecular Weight:334.21
105-54-4
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Yield:859169-90-7 82%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 60; for 1 h;
Steps:
1.B Step B: 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]butyric acid ethyl ester
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol obtained from Step A (0.32 g, 1.4 mmol) was dissolved in 5 mL of DMF. K2CO3 (0.39 g, 2.8 mmol) and 4-butyric acid ethyl ester (0.22 mL, 1.54 mmol) were added thereto, and the mixture was stirred for 1 hour at 60. Solids were removed and the mixture was purified by column chromatography to obtain the title compound (0.38 g, 82 %). 1H NMR (CDCl) δ 7.73 (2H, d), 6.87 (2H, d), 4.14 (2H, q), 4.03 (2H, t), 2.51 (2H, t), 2.11 (2H, m), 1.32 (12H, s), 1.25 (3H, t)
References:
WO2014/209034,2014,A1 Location in patent:Paragraph 400; 405; 406; 407
2969-81-5
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73183-34-3
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106-48-9
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