6-amino-1-methyl-2-oxo-1,2-dihydro-5-pyrimidinecarboxylic acid synthesis

2synthesis methods

Product Name:6-amino-1-methyl-2-oxo-1,2-dihydro-5-pyrimidinecarboxylic acid
CAS Number:88394-20-1
Molecular formula:C6H7N3O3
Molecular Weight:169.14

5-Pyrimidinecarboxylic acid, 6-amino-1,2-dihydro-1-methyl-2-oxo-, ethyl ester

90091-17-1
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6-amino-1-methyl-2-oxo-1,2-dihydro-5-pyrimidinecarboxylic acid

88394-20-1
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Yield:88394-20-1 92.2%

Reaction Conditions:

with water in ethanol at 78; for 9 h;

Steps:

Formation of compound IV

60 gr of water was added to the reaction mixture of XXIII, heated to 78 degrees for 9 hours. After reaction completion, the solution cooled down to r.t., acidified with 32% HC1 to pH 2. The solid filtered off and dried in the oven to yield 22.2 gr of 92.2% compound IV. (total yield from ethyl cyanoacetate 69%)

References:

WO2021/59160,2021,A1 Location in patent:Page/Page column 233

2-Propenoic acid, 2-cyano-3-[[(methylamino)carbonyl]amino]-

727722-49-8
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88394-20-1
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References