ChemicalBook CAS DataBase List 9-Fluorenone

9-Fluorenone synthesis

12synthesis methods

Product Name:9-Fluorenone
CAS Number:486-25-9
Molecular formula:C13H8O
Molecular Weight:180.2

Fluorenone can be produced by catalytic oxidation of fluorene, or of fluorene fractions in the presence of a quarternary ammonium salt, or by catalytic oxidative cracking (oxicracking) of a suitable aromatic.

2157-52-0
106 suppliers
$9.00/1g

486-25-9
454 suppliers
$5.00/25g

Yield:486-25-9 98%

Reaction Conditions:

with lithium hydroxide monohydrate;oxygen in acetonitrile at 60; under 760.051 Torr; for 2 h;Autoclave;Green chemistry;

Steps:

General experimental procedure for deoximation to the corresponding carbonyl compounds

General procedure: Oximes (1.0 mmol), Amberlyst-15 (0.02 g), FPA53-NO2(0.02 g), and solvent (1.5 mL) were introduced into a 25-cm-high, 90-mL autoclave with a glass tube inside equipped with magnetic stirrer (Scheme 2). Then the autoclave was charged with oxygen to 0.1 MPa. The reaction mixture was stirred at desirable temperature for special time. Progress of the reaction was monitored by thin-layer chromatography (TLC) or gas chromatography (GC). After the reaction, the resin (Amberlyst-15 and FPA53-NO2) was separated from the reaction mixture by filtration and extracted with 3 mL CH3CN (2 1.5 ml). The solvent was removed under reduced pressure. The residue was further purified by column chromatography on silica gel (300 mesh) with hexane/ethyl acetate to give the corresponding carbonyl compounds.

References:

Guo, Shu;Zeng, Renyou;Li, Caiye [Synthetic Communications,2016,vol. 46,# 17,p. 1446 - 1453] Location in patent:supporting information