(2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid synthesis

3synthesis methods

Product Name:(2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid
CAS Number:96522-37-1
Molecular formula:C14H17NO5
Molecular Weight:279.29

13504-85-3 Synthesis

13504-85-3
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74-88-4
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(2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid

96522-37-1
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Yield:96522-37-1 91%

Reaction Conditions:

Stage #1: (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acidwith sodium hydride in tetrahydrofuran;dimethyl sulfoxide;mineral oil at -20 - 0;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran;dimethyl sulfoxide;mineral oil at -20 - 25; for 24 h;Inert atmosphere;chemoselective reaction;

References:

Mihali, Voichita;Foschi, Francesca;Penso, Michele;Pozzi, Gianluca [European Journal of Organic Chemistry,2014,vol. 2014,# 24,p. 5351 - 5355] Location in patent:supporting information

51-35-4 Synthesis

51-35-4
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96522-37-1
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References

501-53-1
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96522-37-1
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References