ChemicalBook CAS DataBase List ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT

ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT synthesis

3synthesis methods

Product Name:ALPHA-KETOGLUTARIC ACID MONOSODIUM SALT
CAS Number:22202-68-2
Molecular formula:C5H5NaO5
Molecular Weight:168.08

328-50-7 Synthesis

328-50-7
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22202-68-2
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Yield:-

Reaction Conditions:

with sodium hydride in tetrahydrofuranProduct distribution / selectivity;

Steps:

5; 6; 7; 8; 9; 10; 11; 12
2-oxo-pentanedioic acid was dissolved in THF under nitrogen. To this solution was addedone equivalent of NaH. The resulting sodium salt of the a-keto acid was then treateddropwise with one equivalent of (1R, 2R, 4S)-2-bromo-1-isopropyl-4-methyl-cyclohexaneover a period of 100 hours. See, for example, Domagala, 1980.

References:

CANCER RESEARCH TECHNOLOGY LIMITED WO2006/16143, 2006, A1 Location in patent:Page/Page column 60; 61; 62; 63

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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529-96-4
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$320.00/0.01g

22202-68-2
80 suppliers
$15.00/1g

References

142-47-2
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$5.00/100g

22202-68-2
80 suppliers
$15.00/1g

References