Amikacin Disulfate synthesis

Yield:39831-55-5 91.5%

Reaction Conditions:

with sulfuric acid in ethanol;water at 10; for 6 h;Temperature;

Steps:

1.2-1.3; 2.2-2.3
(2) Intermediate I was dissolved by adding 600 ml of ethanol, and 100 g of a 50% sulfuric acid aqueous solution was added dropwise at a temperature controlled below 10 ° C in ice water.After the dropwise addition was completed, the mixture was kept under stirring for 6 hours and filtered to obtain 104.4 g of crude amikacin sulfate with a yield of 66.78%;(3) Refining: Add 104 g of crude amikacin sulfate to the reaction flask, add 800 ml of methanol, and beat under reflux for 4 h.The temperature was reduced to room temperature and filtered, and the ethanol was washed at 50-55 ° C to obtain 95.2 g of amikacin sulfate with a yield of 91.5%.

References:

Hainan Dunsi Pharmaceutical Technology Co., Ltd.;Shanxi Dunsi Pharmaceutical Co., Ltd.;Yining Aierxing Knowledge Property Right Services Co., Ltd.;Wang Ming CN110862424, 2020, A Location in patent:Paragraph 0037; 0039-0041; 0043-0044

FullText