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ChemicalBook CAS DataBase List AMINO-(3-TRIFLUOROMETHYL-PHENYL)-ACETIC ACID

AMINO-(3-TRIFLUOROMETHYL-PHENYL)-ACETIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: isobutyl nitrite, aq. KOH / methanol / 26 h / 50 - 90 °C
2: H2, conc aq. HCl / 5percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

References:

Shuman;Rothenberger;Campbell;Smith;Gifford-Moore;Gesellchen [Journal of Medicinal Chemistry,1993,vol. 36,# 3,p. 314 - 319]