ChemicalBook CAS DataBase List Aminopyrazine

Aminopyrazine synthesis

11synthesis methods

Product Name:Aminopyrazine
CAS Number:5049-61-6
Molecular formula:C4H5N3
Molecular Weight:95.1

19847-12-2
332 suppliers
$6.00/5g

5049-61-6
416 suppliers
$8.00/10g

Yield:5049-61-6 82.6%

Reaction Conditions:

with sodium hypochlorite;sodium hydroxide at 20 - 60; for 5 h;

Steps:

1 Example 1,Preparation of 2-amino-pyrazine
A 500ml three-neck flask, was added at a concentration of 20% sodium hydroxide (30g) solution, and sodium hypochlorite solution (100ml), was added 2-cyano-pyrazine (21g, 0.2mol) at room temperature, the reaction was stirred for 1h. Then for 4h at 50 ~ 60 , with dichloromethane (4 × 200ml) was extracted, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give a white solid 15.7g, yield 82.6%.

References:

Hubei University of Technology;Liu, Mingxing;Jiang, Weidong;Wang, Wanxia CN105622526, 2016, A Location in patent:Paragraph 0020; 0021; 0022

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32111-21-0 Synthesis