Benzothiazole, 7-bromo- (7CI,8CI) synthesis
- Product Name:Benzothiazole, 7-bromo- (7CI,8CI)
- CAS Number:767-70-4
- Molecular formula:C7H4BrNS
- Molecular Weight:214.08
769-20-0
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$45.00/50mg
767-70-4
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$80.00/50 mg
Yield: 75%
Reaction Conditions:
Stage #1:6-amino-7-bromo-1,3-benzothiazole with sulfuric acid;sodium nitrite at 20; for 0.333333 h;
Stage #2: with hypophosphorous acid at 50;
Stage #3: with sodium carbonate; pH=9 - 10
Steps:
30
Example 30; 7-Bromo-benzothiazoleSodium nitrite (0.229 g, 3.3 mmol) was added to a solution of 7-bromo-benzothiazol-6-ylamine (0.380 g, 1.66 mmol, described in WO 97/31636) in sulfuric acid (10 mL) and the resulting mixture was stirred at room temperature for 20 min. Hypophosphorous acid (10 mL) was added and the mixture was heated at 50° C. overnight. The pH was adjusted to 9-10 by addition of sodium carbonate, and the crude product was removed by filtration and washed with water. Purification by prep-HPLC gave 0.265 g (75% yield) of the title compound as a white solid: LC-MS (EI) m/z 213 (M++1).
References:
AstraZeneca AB US2011/98292, 2011, A1 Location in patent:Page/Page column 1
533-30-2
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767-70-4
85 suppliers
$80.00/50 mg
1123-55-3
87 suppliers
$56.00/100 mg
767-70-4
85 suppliers
$80.00/50 mg