ChemicalBook CAS DataBase List Betulonicacid

Betulonicacid synthesis

6synthesis methods

Product Name:Betulonicacid
CAS Number:4481-62-3
Molecular formula:C30H46O3
Molecular Weight:454.68

472-15-1
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$5.00/25mg

4481-62-3
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$25.00/5mg

Yield:4481-62-3 93%

Reaction Conditions:

with Jones reagent in dichloromethane;acetone at 20; for 0.25 h;Cooling;

Steps:

3.2.11 Betulonic acid (7)
Jones’ reagent: CrO3 (26.72 g) was dissolvedin H2SO4 (23 ml); then, the solutionwas diluted to 100 ml with water. Asolution of BA (500 mg, 1.09mmol) inCH2Cl2 (12 ml) and acetone (12 ml) wascooled, to which Jones’ reagent (1 ml) wasslowly added. The mixture was stirred atroom temperature for 15 min; then, MeOH(5 ml) was added. After another stirring for10 min, CH2Cl2 (20 ml) was added and theorganic layer was washed with water andsaturated NaCl solution sequentially, driedover anhydrous Na2SO4, and concentratedin vacuo. The product was recrystallized inMeOH for three times as a white solid(462 mg, 93%).

References:

Liu, Jin-Hong;Tang, Jia;Zhu, Zi-Fei;Chen, Li [Journal of Asian Natural Products Research,2014,vol. 16,# 1,p. 34 - 42]

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473-98-3 Synthesis