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ChemicalBook CAS DataBase List Brivaracetam (alfaR, 4R)-Isomer

Brivaracetam (alfaR, 4R)-Isomer synthesis

2synthesis methods
63095-51-2 Synthesis
(R)-4-Propyldihydrofuran-2(3H)-one

63095-51-2
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$39.00/100mg

Brivaracetam (alfaR, 4R)-Isomer

357337-00-9
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: trimethylsilyl bromide / dichloromethane / 6 h / 20 °C / Inert atmosphere
2: sodium carbonate / ethanol / 16 h / 50 °C

References:

Liao, Shouzhu;Chen, Hongjun;Wang, Guifei;Wu, Shuming;Yang, Zaiyou;Luo, Weihe;Liu, Zhuanfeng;Gao, Xun;Qin, Junhai;Li, Chuan-hua;Wang, Zhongqing [Tetrahedron,2020,vol. 76,# 26,art. no. 131273]

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