Calcium 2-oxoglutarate synthesis
- Product Name:Calcium 2-oxoglutarate
- CAS Number:71686-01-6
- Molecular formula:C5H8CaO5
- Molecular Weight:188.19
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Yield:71686-01-6 77%
Reaction Conditions:
with calcium chloride in water at 65 - 70;Large scale;
Steps:
1
Example 1. Synthesis of Ca-AKG using NaOH (250 g scale). Sodium hydroxide (150 g, 3.76 mol) was dissolved in 1000 mL water. alpha-Ketoglutaric acid (250.0 g, 1.71 mol) was added at 25- 35°C. The solution was stirred for 2-3 hour at 25-35°C. Calcium chloride (569 g, 5.13 mol, 3.0 eq) dissolved into 1000 mL of water was added to the reaction mass at 25-35°C. The reaction mass was stirred at 65-70°C for 4-5 hours. The resultant precipitate was collected and washed with 500 mL of water. The solid was dried at 80-90°C for 6 hours to give 265 g (77% yield).
References:
WO2020/68705,2020,A1 Location in patent:Page/Page column 37
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