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ChemicalBook CAS DataBase List gamma-Cyclodextrin

gamma-Cyclodextrin synthesis

5synthesis methods
Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
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Yield:-

Reaction Conditions:

with Bacillus macerans glucanotransferase in aq. phosphate buffer; pH=7.5 at 25; for 6 h;Enzymatic reaction;

References:

Larsen, Dennis;Beeren, Sophie R. [Chemical Science,2019,vol. 10,# 43,p. 9981 - 9987]

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