DEXCHLORPHENIRAMINE synthesis
- Product Name:DEXCHLORPHENIRAMINE
- CAS Number:25523-97-1
- Molecular formula:C16H19ClN2
- Molecular Weight:274.79
1679-18-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: di-μ-chloro-bis[bis(cyclo-octene)rhodium]; (R)-(+)-(4,4'-bi-1,3-benzodioxole)-5,5'-diylbis(di(3,5-dimethylphenyl)phosphine); potassium hydroxide / tetrahydrofuran; water / 12 h / 80 °C / Inert atmosphere; Schlenk technique
2.1: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: pH 6 / Inert atmosphere; Schlenk technique
3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 12 h / 20 °C / Inert atmosphere; Schlenk technique
4.1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux
References:
Zhu, Huilong;Yin, Long;Chang, Zhiqian;Wang, Yuhan;Dou, Xiaowei [Advanced Synthesis and Catalysis,2020,vol. 362,# 15,p. 3142 - 3147]
7340-23-0
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25523-97-1
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