DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE synthesis
2synthesis methods
- Product Name:DIMETHYL-3-CHLORO-2-OXOPROPYLPHOSPHONATE
- CAS Number:60378-99-6
- Molecular formula:C5H10ClO4P
- Molecular Weight:200.56
Yield:60378-99-6 73%
Reaction Conditions:
Stage #1: dimethyl methane phosphonatewith n-butyllithium in tetrahydrofuran at -78; for 0.5 h;
Stage #2: with copper(l) chloride in tetrahydrofuran at -78 - -30; for 1 h;
Stage #3: chloroacetyl chloride in tetrahydrofuran;diethyl ether at -30 - 20;
References:
Yuan, Cheng-Ye;Wang, Ke;Li, Zu-Yi [Heteroatom Chemistry,2001,vol. 12,# 6,p. 551 - 556]
