ChemicalBook CAS DataBase List DIPHENYL METHYLPHOSPHONATE

DIPHENYL METHYLPHOSPHONATE synthesis

11synthesis methods

Product Name:DIPHENYL METHYLPHOSPHONATE
CAS Number:7526-26-3
Molecular formula:C13H13O3P
Molecular Weight:248.21

4712-55-4
181 suppliers
$10.00/5g

74-88-4
339 suppliers
$15.00/10g

7526-26-3
34 suppliers
$130.00/1g

Yield: 80%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile at 0 - 20; for 2 h;

Steps:

General procedure for H-phosphonate alkylation
General procedure: To a stirred solution of Hphosphonate (3 mmol, 1 equiv) in CH3CN (6 mL) was added the halide (3.3 mmol, 1.1 equiv) and DBU (0.5 mL, 3.3 mmol, 1.1 equiv) at 0°C. The stirred mixture was allowed to warm to rt over 2 h. The organic layer was washed with hexane (2x). The residue obtained upon evaporation was purified by column chromatography over silica gel (hexane to EtOAc) to give the expected phosphonate.

References:

Gavara, Laurent;Petit, Christelle;Montchamp, Jean-Luc [Tetrahedron Letters,2012,vol. 53,# 37,p. 5000 - 5003] Location in patent:supporting information