ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate synthesis

5synthesis methods

Product Name:ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate
CAS Number:85828-82-6
Molecular formula:C17H16I2O4
Molecular Weight:538.12

Benzeneacetic acid, 3,5-diamino-4-(4-methoxyphenoxy)-, ethyl ester

101588-11-8
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ethyl 3,5-diiodo-4-(4-methoxyphenoxy)phenylacetate

85828-82-6
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$140.00/100mg

Yield:85828-82-6 69%

Reaction Conditions:

Stage #1: C₁₇H₂₀N₂O₄with sulfuric acid;acetic acid;sodium nitrite at 0; for 1.75 h;
Stage #2: with iodine;urea;sodium iodide in chloroform;water at 20; for 1 h;

Steps:

[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid (8)The title compound was prepared as described by Wilkinson J H Synthesis of some Possible Metabolites of Thyroxin and Triiodothyronine Biochem J. 1956 August; 63(4):601-605.

References:

US2011/105482,2011,A1 Location in patent:Page/Page column 10