ChemicalBook CAS DataBase List FMOC-SARCOSINE MONOHYDRATE

FMOC-SARCOSINE MONOHYDRATE synthesis

4synthesis methods

Product Name:FMOC-SARCOSINE MONOHYDRATE
CAS Number:77128-70-2
Molecular formula:C18H17NO4
Molecular Weight:311.33

107-97-1 Synthesis

107-97-1
570 suppliers
$5.00/100mg

82911-69-1 Synthesis

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1
599 suppliers
$7.00/25g

77128-70-2
190 suppliers
$10.00/5g

Yield:77128-70-2 98%

Reaction Conditions:

with sodium hydrogencarbonate in 1,4-dioxane;water at 20; for 5 h;

Steps:

(9-Fluorenylmethyloxycarbonyl(methyl)amino)acetic acid (S7)
To a solution of sarcosine (500 mg, 5.61 mmmol) in saturated NaHCO3 (10 ml) were added solution of Fmoc-OSu (1.99 g, 5.90 mmol) in 1,4-dioxane (10 ml) and the mixture was stirred for 5 h. Saturated NH4Cl and AcOEt was added to the solution and organic layer was washed with brine, dried over MgSO4 and evaporated in vacuo. The residue was purified with column chromatography (CHCl3:MeOH = 80:20 v/v) to give S7 (1.71 g, 5.49 mmol, 98%) as a white solid.

References:

Sato, Ryota;Oyama, Kie;Konno, Hiroyuki [Tetrahedron,2018,vol. 74,# 42,p. 6173 - 6181] Location in patent:supporting information

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