IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE synthesis
- Product Name:IMIDAZO[1,2-A]PYRIDIN-3-YL-ACETONITRILE
- CAS Number:17744-98-8
- Molecular formula:C9H7N3
- Molecular Weight:157.17
![3-[(DIMETHYLAMINO)METHYL]IMIDAZO[1,2-A]PYRIDINE](/CAS/GIF/2717-95-5.gif)
Yield:17744-98-8 5.1%
Reaction Conditions:
Stage #1: 1-(imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanaminewith dimethyl sulfate in tetrahydrofuran; for 0.5 h;Reflux;
Stage #2: sodium cyanide in water; for 1 h;Reflux;
References:
Shultz, Michael D.;Cao, Xueying;Chen, Christine H.;Cho, Young Shin;Davis, Nicole R.;Eckman, Joe;Fan, Jianmei;Fekete, Alex;Firestone, Brant;Flynn, Julie;Green, Jack;Growney, Joseph D.;Holmqvist, Mats;Hsu, Meier;Jansson, Daniel;Jiang, Lei;Kwon, Paul;Liu, Gang;Lombardo, Franco;Lu, Qiang;Majumdar, Dyuti;Meta, Christopher;Perez, Lawrence;Pu, Minying;Ramsey, Tim;Remiszewski, Stacy;Skolnik, Suzanne;Traebert, Martin;Urban, Laszlo;Uttamsingh, Vinita;Wang, Ping;Whitebread, Steven;Whitehead, Lewis;Yan-Neale, Yan;Yao, Yung-Mae;Zhou, Liping;Atadja, Peter [Journal of Medicinal Chemistry,2011,vol. 54,# 13,p. 4752 - 4772] Location in patent:experimental part
![Imidazo[1,2-a]pyridine](/CAS/GIF/274-76-0.gif)
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