ChemicalBook CAS DataBase List L-Glutamic acid α-tert·butyl ester

L-Glutamic acid α-tert·butyl ester synthesis

5synthesis methods

Product Name:L-Glutamic acid α-tert·butyl ester
CAS Number:45120-30-7
Molecular formula:C9H17NO4
Molecular Weight:203.24

5891-45-2 Synthesis

5891-45-2
140 suppliers
$6.00/1g

45120-30-7
233 suppliers
$5.00/1g

Yield:45120-30-7 11.55 g (77%)

Reaction Conditions:

palladium-carbon in methanol;

Steps:

29.A Step A

Step A Preparation of (S)-2-aminopentanedioic acid 1-tert.-butyl ester To a solution of 25.0 g (74.1 mmol) (S)-2-(benzyloxycarbonylamino)pentanedioic acid 1-tert.-butyl ester (prepared according to Liebigs Ann. Chem. 1961, 646, 127) in 500 ml dry methanol were added 2.5 g 10% Pd/C, and the mixture was stirred over night at room temperature under an atmosphere of hydrogen. The catalyst was removed by filtration through celite and the filtrate was concentrated under reduced pressure. The remaining solid title compound was purified by stirring with a small amount of ethanol, filtered with suction, and dried in vacuo. Another crop (1.7 g) was obtained after concentration of the mother liquid and stirring of the residue with ethyl acetate. total yield: 11.55 g (77%), white powder, m.p. 114-116° C.

References:

US6291469,2001,B1

84793-07-7 Synthesis