Leuprorelin acetate synthesis

Leuprolide acetate is a commonly used hormone anticancer drug. It is the acetate salt of leuprolide, a synthetic nonapeptide analog of gonadotropin-releasing hormone (LHRH, a decapeptide). It belongs to LH-RH. Antagonist, LHRH is produced by the hypothalamus, which can induce the anterior pituitary to release gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). A method for preparing leuprorelin acetate - pGlu-His(Trt)-Trp-Ser(tBu)-Tyr(tBu)-D-Leu-Leu-Arg(Pbf)-Pro-OH and Ethylamine synthesis reaction.