Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate synthesis
- Product Name:Methyl 5-Benzyloxy-4-Methoxy-2-nitrobenzoate
- CAS Number:164161-49-3
- Molecular formula:C16H15NO6
- Molecular Weight:317.29
215659-03-3
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Yield: 97%
Reaction Conditions:
with potassium carbonate in acetonitrile at 80; for 4 h;
Steps:
2 Step 2
Methyl 5-(benzyloxy)-4-methoxy-2-nitrobenzoate A solution of the product from the previous step (5.3 g, 23 mmol), (bromomethyl)benzene (6.0 g, 35 mmol) and K2CO3(6.3 g, 46 mmol) in MeCN (100 mL) was stirred at 80 °C for 4 h. The solvent was removed, the residue taken up in water, and the product extracted with EtOAc. The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated to give the title compound as a yellow solid (7 g, 97%). MS (ES+) C16H15NO6 requires: 317, found: 318[M+H]+.
References:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;HEYMACH, John;ROBICHAUX, Jacqulyne;NILSSON, Monique;JONES, Philip;CROSS, Jason;THEROFF, Jay WO2020/219904, 2020, A1 Location in patent:Paragraph 0474
57535-57-6
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